Abstract: Special-shaped multicell composite concrete-filled steel tube (CFT) columns have been used in several super-high-rise buildings. However, research on special-shaped multicell CFT columns under low cyclic loading remains limited. Thus, seven 1=30-scaled specimens were designed for a low cyclic loading test. The parameters are four cross-section structures (i.e., the basic type, angle steel reinforced type, circular steel tube reinforced type, and simplified type) and three loading directions (i.e., the long axis, short axis, and 45°). The failure modes, hysteretic behavior, bearing capacity, ductility, and energy-dissipation capacity were analyzed. The results show that the angle steel and circular steel tube significantly increase the bearing capacity and energy dissipation. The circular steel tube has a better effect than the angle steel. The bearing capacity of the simplified-type specimens decreases but the ductility increases. When the loading direction changes from the long axis to the short axis, the ductility gradually increases, whereas the bearing capacity and energy-dissipation capacity gradually decrease. The optimized models of the fiber-based method (FBM) were proposed to predict the N-M curves and F-Δ curves. The concrete constitutive relationship in the multicell CFTwas proposed based on the separation model by analyzing the features of multicell CFT columns and was used in the optimized fiber-based method. The numerical simulation models were established using Abaqus to simulate the F-Δ curves for FBM models and test. The calculation results show good consistency with the test.